Selected Publications

Hookworm Pathogenesis

Vermeire JJ, Cho Y, Lolis E, Bucala R, Cappello M. Macrophage migration inhibitory factor (MIF) orthologues of parasitic nematodes. Parasitol Today 2008;24:355-63

Dondji B, Bungiro RD, Harrison LM, Bifulco C, Vermeire J, McMahon-Pratt D, Cappello M. A role for nitric oxide in hookworm associated immune suppression Infect Immun 2008;76:2560-7

Bungiro RD, Sun T, Harrison LM, Shoemaker CB, Cappello M. Mucosal antibody responses in experimental hookworm infection Parasite Immunol 2008;30:2293-303

Cho Y, Jones BF,  Vermeire JJ, Leng L, DiFedele LM, Harrison LM, Xiong H, Kwong Y, Chen Y, Bucala R, Lolis E, Cappello M. Structural and functional characterization of a secreted hookworm macrophage migration inhibitory factor that interacts with the human MIF receptor CD74. J Biol Chem 2007;282:23447

Brown AC, Harrison LM, Kapulkin W, Jones BF, Sinha A, Savage M, Villalon N, Cappello M. Molecular cloning and characterization of a C-type lectin from Ancylostoma ceylanicum: evidence for a role in hookworm reproductive physiology. Mol Biochem Parasitol 2007;151:141-7

Cappello M, Bungiro RD, Harrison LM, Bischoff L, Griffitts J, Barrows B, Aroian RV. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proc Natl Acad Sci USA 2006:103:15154-9

Held M, Bungiro RD, Harrison LM, Hamza I, Cappello M. Dietary iron mediates hookworm pathogenesis in vivo. Infect Immun 2006;74:289-295

Bungiro RD, Cappello M. Detection of Hookworm Excretory/Secretory Antigens in the Feces of Experimentally Infected Animals by Enzyme-Linked Immunosorbent Assay. Am J Trop Med Hyg 2005;73:915-20

Jones BF, Cappello M. Mechanisms of Disease: Hookworm. Drug Discov Today 2004;1:217-22

Bungiro RD, Cappello M. Hookworm infection: new developments and prospects for control. Curr Opin Infect Dis 2004;17:421-6

Cappello M. The global health impact of soil transmitted nematodes. Ped Infect Dis J 2004;23:663-4

Chu D, Ibanez M, Campodonico E, Bungiro RD, Harrison LM, Mieszczanek J, Jones BF, Kuzmic P, Cappello M. Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: Evidence for a role in hookworm associated growth delay. Infect Immun 2004;72:2214-2221

Bungiro RD, Solis C, Harrison LM, Cappello M. Purification and molecular cloning of and immunization with Ancylostoma ceylanicum Excretory/Secretory Protein 2 (AceES-2), an immunoreactive protein produced by adult hookworms. Infect Immun 2004;72:2203-2213

Mieszczanek J, Harrison LM, Vlasuk GP, Cappello M. Anticoagulant peptides from Ancylostoma caninum are immunologically distinct and localize to separate structures within the adult hookworm. Mol Biochem Parasitol 2004;133:319-23

Cappello M, Harrison LM, Bungiro RD, Chadderdon CR, Del Valle A, Milstone AM, Chu D, Mieszczanek J, Nerlinger A, Kuzmic P. Molecular pathogenesis of hookworm anemia: prospects for a disease based vaccine. J Parasitol 2003;89:S158-64

Del Valle A, Jones BF, Harrison LM, Chadderdon RC, Cappello M. Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum. Mol Biochem Parasitol 2003;129:167-77

Bungiro RD, Anderson BR, Cappello M. Oral transfer of adult Ancylostoma ceylanicum hookworms into permissive and non-permissive hosts. Infect Immun 2003;71:1880-8

Harrison LM, Nerlinger A, Bungiro RD, Còrdova J, Kuzmic P, Cappello M. Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa: hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo. J Biol Chem 2002;277:6223-9

Bungiro RD, Harrison LM, Cappello M. Ancylostoma ceylanicum Excretory/Secretory Protein 1: Purification and molecular cloning of a major secretory protein from adult hookworms. Mol Biochem Parasitol 2002;119:147-51

Harrison LM, Cordova JL, Cappello M. Ancylostoma caninum Anticoagulant Peptide-5: Immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic. Mol Biochem Parasitol 2001;115:101-7

Bungiro RD, Greene J, Kruglov E, Cappello M. Mitigation of hookworm disease following immunization with soluble extracts of Ancylostoma ceylanicum. J Infect Dis 2001;183:1380-7

Milstone AM, Harrison LM, Bungiro RD, Kuzmic P, Cappello M. A broad spectrum Kunitz-type serine protease inhibitor secreted by the hookworm, Ancylostoma ceylanicum. J Biol Chem 2000;275:29391-9

Chadderdon RC, Cappello M. The hookworm platelet inhibitor: functional blockade of GPIIb/IIIa and GPIa/IIa inhibits platelet aggregation and adhesion in vitro. J Infect Dis 1999;179:1235-41

Cappello M, Vlasuk GP, Bergum P, Huang S, Hotez PJ. Ancylostoma caninum Anticoagulant Peptide: a hookworm-derived inhibitor of human coagulation factor Xa. Proc Natl Acad Sci USA 1995;92:6152-6

Cappello M, Clyne LP, McPhedran P, Hotez PJ. Ancylostoma factor Xa inhibitor: Partial purification and its identification as a major hookworm-derived anticoagulant in vitro. J Infect Dis 1993;167:1474-7

Antithrombotic strategies of bloodfeeding arthropods

Ledizet M, Harrison LM, Koski RA, Cappello M. Discovery and Pre-clinical development of anti-thrombotics from hematophagous invertebrates. Current Medicinal Chemistry-Cardiovascular and Hematological Agents. 2005;3:1-10

Jiang X, Bailly MA, Panetti TS, Cappello M, Konigsberg WH, Bromberg ME. Formation of Tissue Factor-Factor VIIa-Factor Xa complex promotes cellular signaling and migration of human breast cancer cells. J Thromb Haemost 2004;2:93-101

Narasimhan S, Koski R, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis. Insect Mol Biol 2002;11:641-50

Bromberg M, Cappello M. Cancer and blood coagulation: molecular aspects. Cancer J Sci Am 1999;5:132-8

Cappello M, Li S, Chen X, Li CB, Narasimhan S, Harrison L, Beard CB, Aksoy S. Tsetse Thrombin Inhibitor: Bloodmeal induced expression of an anticoagulant in salivary glands and gut tissue of Glossina morsitans morsitans. Proc Natl Acad Sci USA 1998;95:14290-5

 Donnelly KM, Bromberg ME, Milstone A, Madison McNiff J, Terwilliger G, Konigsberg WH, Cappello M. Ancylostoma caninum Anticoagulant Peptide blocks metastasis in vivo and inhibits factor Xa binding to melanoma cells in vitro. Thromb Haemost 1998;79:1041-7

Cappello M, Bergum P, Vlasuk GP, Furmidge B, Pritchard DI, Aksoy S. Isolation and characterization of Tsetse Thrombin Inhibitor (TTI): a potent antithrombotic peptide from the saliva of Glossina morsitans morsitans. Am J Trop Med Hyg 1996;54:475-80